Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Silencing circRNA_100367 inhibited the proliferation and migration of KYSE-150R cells, and decreased the expression of β-catenin (an important molecule in Wnt pathway) in KYSE-150R cells.
|
31851619 |
2019 |
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
<b>Conclusion:</b> SOX2, β-catenin and survivin can be used as prognostic markers of esophageal squamous cell carcinoma.
|
31789057 |
2019 |
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
Tex10 promotes stemness and EMT phenotypes in esophageal squamous cell carcinoma via the Wnt/β‑catenin pathway.
|
31638260 |
2019 |
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
Downregulation of nicotinamide N-methyltransferase inhibits migration and epithelial-mesenchymal transition of esophageal squamous cell carcinoma via Wnt/β-catenin pathway.
|
31278587 |
2019 |
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
Collectively, the present results indicated that HIF‑1α may regulate the stemness of ESCC by activating the Wnt/β‑catenin pathway.
|
31233197 |
2019 |
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
<b>Methods:</b> qRT-PCR was used to detect the levels of FEZF1-AS1 and mRNA CTNNB1 (β-catenin) in ESCC tissues and cells.
|
31191005 |
2019 |
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
Mechanically, we demonstrated PRR11-enhanced tumorigenicity of ESCC cells via activating Wnt/β-catenin signaling, and PRR11 expression is found to be significantly correlated with β-catenin nuclear location in ESCC.
|
31040705 |
2019 |
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
Further study of these genes could be useful to understand the molecular pathology of ESCC with respect to epithelial-mesenchymal transition (EMT) mediated by Wnt/β-catenin and TGF-β signaling pathways.
|
30880778 |
2019 |
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Mechanistically, we demonstrated that GPC1 increased levels of p-Akt and β-catenin and reduced PTEN expression in ESCC.
|
30730015 |
2019 |
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
DUXAP8 may promote the occurrence of ESCC via Wnt/β-catenin pathway.
|
29771416 |
2018 |
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In the vitro experiments, knocking down the expression of PBR inhibited proliferation, colony formation and migration of ESCC cells, and regulated EMT-associated proteins (up-regulation of E-cadherin, ZO-1 and β-catenin and concomitant with down-regulation of Fibronectin and N-cadherin).
|
29158807 |
2017 |
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
Msi2 plays a carcinogenic role in esophageal squamous cell carcinoma via regulation of the Wnt/β-catenin and Hedgehog signaling pathways.
|
29054489 |
2017 |
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The mRNA and protein expression levels of zinc finger protein SNAI1 (Snail) and β‑catenin in ESCC were significantly higher compared with para-carcinoma tissues, whereas E‑cadherin mRNA and protein expression levels were lower in ESCC tissues compared with in para-carcinoma tissues.
|
28260072 |
2017 |
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
Positive correlation of cysteine-rich 61 and target genes of Wnt/β-catenin pathway in esophageal squamous cell carcinoma.
|
27721245 |
2016 |
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
When placed in stable transfectants of the KYSE 30 ESCC cell line generated by lentiviral transduction with the ectopic overexpression of NDRG1, the expression of transducin-like enhancer of Split 2 (TLE2) was decreased sharply, however β-catenin was increased.
|
27414086 |
2016 |
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
Inhibition of SALL4 reduces tumorigenicity involving epithelial-mesenchymal transition via Wnt/β-catenin pathway in esophageal squamous cell carcinoma.
|
27329034 |
2016 |
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
These data indicate that NRAGE extremely may be a pivotal factor involved in Wnt/β-catenin signal pathway, mediating nuclear translocation of β-catenin and then facilitating the formation of radioresistance of ESCC.
|
26738870 |
2016 |
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/β-catenin pathway.
|
25749389 |
2015 |
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Krüppel-like factor 9 was down-regulated in esophageal squamous cell carcinoma and negatively regulated beta-catenin/TCF signaling.
|
25641762 |
2016 |
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
It has been reported that RBMS3 directly binds to the promoter region of c-Myc in ESCC and that β-catenin from both whole cell extracts and nuclear fractionation was significantly downregulated in RBMS3-transfected NPC cells compared to control cells.
|
25588924 |
2015 |
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In addition, Aurora-A overexpression is significantly correlated with increased cytoplasmic β-catenin expression in ESCC tissues.
|
25217103 |
2015 |
Squamous cell carcinoma of esophagus
|
0.500 |
GeneticVariation
|
disease |
CLINVAR |
Prospective enterprise-level molecular genotyping of a cohort of cancer patients.
|
25157968 |
2014 |
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
Taken together, this study reveals critical mechanisms involved in the role of RelA/PLK1/β-catenin in anoikis resistance of ESCC cells.
|
21610149 |
2011 |
Squamous cell carcinoma of esophagus
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The overexpression of Wnt1/beta-catenin mRNA should also predict poor prognosis of ESCC; however, it might not be an independent prognostic factor.
|
20491588 |
2010 |
Squamous cell carcinoma of esophagus
|
0.500 |
Biomarker
|
disease |
BEFREE |
beta-Catenin/TCF pathway plays a vital role in selenium induced-growth inhibition and apoptosis in esophageal squamous cell carcinoma (ESCC) cells.
|
20457486 |
2010 |